A novel green process for synthesis of venlafaxine and its impurities

Abstract
An improved process for synthesis of Venlafaxine from p-methoxyphenylacetonitrile with cyclohexanone using TBAI as phase transfer catalysis to give almost quantitative yields of cycloalkanols, further is reduced using Raney/nickel in methanolic ammonia, acetic acid and dimethylation using dimethyl carbonate/K2CO3 in DMF. The work is also included to identification, synthesis and characterization of process related impurities of venlafaxine

2017050111-A novel green process for synthesis of venlafaxine and its impurities pdf…

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